Top 5 Differences Between Sculptra® and Radiesse®

If you’re dealing with facial volume loss from aging, weight reduction, or GLP-1 use, non-surgical collagen-stimulating injectables like Sculptra® and Radiesse® can be ideal solutions. Both are biostimulators, meaning they’re designed to gradually rebuild the skin’s structural integrity by prompting collagen production. But how do you choose between them?
Here are the top five differences between these two popular injectables:
1. How They Work
- Radiesse®: uses calcium hydroxylapatite (CaHA) microspheres to stimulate collagen and provide structural lift
- Sculptra®: contains poly-L-lactic acid (PLLA), which disperses into the skin to trigger deep collagen regeneration
2. How Fast You See Results
- Radiesse®: Can provide virtually immediate results thanks to its gel-based formula, with collagen-boosting effects continuing over time
- Sculptra®: Takes a gradual approach, with full results appearing over several weeks to months as collagen rebuilds beneath the surface
3. Ideal Use Cases
- Radiesse®: frequently works well for those wanting faster results, such as for events or a more immediate rejuvenation boost
- Sculptra®: often ideal for those seeking subtle, long-term improvement
4. Treatment Areas
- Radiesse®: well-suited for moderate to severe folds and hollows needing structural support, such as cheeks, nasolabial folds, and hand volume loss
- Sculptra®: best for global facial volume restoration, subtle rejuvenation, smoothing lines/wrinkles, restoring skin support and elasticity
5. Onset vs. Longevity
- Radiesse®: generally provides a quick visual improvement and continues working over time
- Sculptra®: produces results that emerge more slowly, but often last two years or more, especially with proper skincare and maintenance
Supporting Your Results With Skincare
To support and extend the benefits of either injectable, we recommend pairing your treatment with medical-grade skincare. Products like sunscreens, antioxidant serums, moisturizers, and barrier repair agents can protect your results, promote healthy skin turnover, and enhance overall glow.
Which One Is Right for You?
Both Sculptra® and Radiesse® can provide powerful, non-surgical solutions for restoring facial volume and improving skin quality – especially for patients experiencing age-related changes or volume loss after weight reduction, including GLP-1 use. The right option for you will ultimately depend on your personal goals, timeline, and preferences regarding onset and longevity of results.
At Alexander Ereso Plastic Surgery and Aesthetics, our team can help you determine whether Sculptra® or Radiesse® is best suited to your needs and how each can fit into your larger rejuvenation plan. Whether you’re navigating post-weight loss changes or simply looking to refresh your look, schedule a consultation to explore your options.


